Viewed in different ways, persons with a larger genetic predisposition to weight problems appeared to be more vunerable to the deleterious effects of sugar-sweetened beverages on BMI. Our findings further underscore the need to test interventions that reduce the intake of sweet drinks as a way of reducing the chance of weight problems and related diseases. Our study displays a substantial interaction between a significant dietary factor, the intake of sugar-sweetened beverages, and a genetic-predisposition score with regards to obesity and BMI risk.28,30-34 Major known reasons for the inconsistent results include small samples in previous research and the small effect of an individual genetic variant. Lately, a meta-analysis with a big sample validated a modest interaction between physical activity and FTO variants with regards to obesity risk.36 As expected, due to the modest effect of each individual SNP on BMI, the majority of the individual SNPs didn’t display significant interactions with intake of sugar-sweetened beverages with regards to BMI .We thought we would obtain results preferentially from uncultured samples in order to avoid the additional time necessary for, and the artifacts of, tissue and cell culture. However, knowledge with traditional cytogenetic analysis and confined placental mosaicism in chorionic-villus samples offers occasionally revealed discrepant results between direct evaluation that evaluates predominantly the cytotrophoblast and cultured samples that typically are based on the mesenchymal primary of the villi.16 Microarray analysis of uncultured samples captures the genomic content of both cell lineages. Although our initial comparison of microarray outcomes from paired cultured and uncultured samples was reassuring, the limited sample size makes additional evaluation necessary.