John Krystal, Editor of Biological Psychiatry. ‘This advance also points to cellular signaling mechanisms mediated by Akt1 to be relevant to the biology of cannabis psychosis. This might suggest research directions for novel therapeutics for cannabis psychosis.’ Di Forti agreed, adding that ‘such findings may possibly also help to design health educational promotions tailored to reach those young people at particular risk.’.. AKT1 genotype influences threat of psychotic disorders in cannabis users The power of cannabis to produce psychosis is definitely an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a significant psychotic disorder.Winner says that though this extensive research is preliminary, it is important because while there are seven FDA-approved drugs to treat migraines in adults, there are non-e for teens, who are presently forced to depend on ineffective over-the-counter medications for pain relief often. According to Winner there is a complete insufficient awareness that kids have headaches at all, aside from migraines, which is a under-diagnosed and under-treated population dramatically.