The latter, called HFPEF , affects older individuals and women, and until now there has not really been any treatment available against the disease. The effect showed that sufferers with HFPEF who were treated with ACE-inhibitors or angiotensin receptor blockers – which are commonly used drugs to lessen the blood circulation pressure – experienced better survival than un-treated patients. The difference persisted after adjustment for a lot of other elements, such as patient age, health and wellness and other elements, and the final reduction in mortality was 10 percent.But because destroying the SCN doesn’t affect the body clock that paces feeding behavior, the circadian pacemaker for feeding be somewhere else, Dr. Yanagisawa said. To find the answer, his group do a simple but labor-intensive experiment. The mice are established by The scientists on a regular feeding schedule, then examined their brain tissue to find where Per genes had been fired up in sync with feeding moments. Related StoriesAdvances in whole mount brain imaging: an interview with Patrick Myles, President, Huron Digital PathologyLiposomal sizing and the Coulter principle: an interview with Professor Melvin E. KlegermanMelatonin and the circadian rhythm: an interview with Professor Kennaway, University of AdelaideThe experts put the mice on a 12-hour light/dark cycle, and provided food for four hours in the center of the light portion.