All efficacy analyses were performed on an intention-to-treat basis. The stratified log-rank check was used as the primary analysis for assessment of treatment groups. Cox proportional-hazards modeling was performed while supportive analyses. Subgroup analyses of progression-free survival were performed by way of an interaction test to determine the consistency of the procedure effect according to key baseline characteristics. Overall survival was analyzed with the same strategies as those utilized for the evaluation of progression-free survival. All statistical testing were two-sided, and P values of 0.05 or less were thought to indicate statistical significance. Odds ratios and 95 percent self-confidence intervals were approximated with a logistic-regression model, and hazard ratios and 95 percent confidence intervals were estimated with a Cox proportional-hazards model.In view of the approximately 540 million ALDH2-deficient people in the world, a lot of whom now reside in Western societies, even a small % decrease in esophageal cancers due to a reduction in alcoholic beverages drinking would result in a considerable number of lives saved. Citation:BrooksPJ, Enoch M-A, Goldman D, Li T-K, Yokoyama A The alcoholic beverages flushing response: An unrecognized risk element for esophageal tumor from alcohol intake.PLoS Med 6: e1000050.