Other Analyses The methods that people useful for gene-expression arrays, polymerase-chain-response and sequencing analyses, protein immunoprecipitation, and Western blotting are described in detail in the Supplementary Appendix, available with the full text of this article at NEJM.org. All digital images were enhanced for lighting and contrast with the use of Photoshop Elements 5.0 . Results Clinical Description On ultrasonographic imaging of Fetus 1 and Fetus 2, we observed an abnormal cyst in the cranial region, a big defect in the craniofacial area, an omphalocele, and immotile and hypoplastic limbs . Figure 1C through 1F show the fetuses after the pregnancies had been terminated due to these severe malformations.Our findings also suggest that treatment with recombinant hgh could be considered.. Academics say more open public health interventions needed to tackle ‘lifestyle’ diseases More public health interventions, along the relative lines of the smoking ban, are had a need to tackle Britain's devastating toll of 'lifestyle' diseases, including heart cancers and disease, according to academics. A new paper, by Dr Stanley Blue, lecturer in Social Sciences at The University of Manchester, statements that there must be a shift in public health policy, with less focus on efforts to change individual behaviour and more attention on breaking social habits and methods that are blindly leading us into bad wellness.