Second, it took 4 to 5 years after randomization for the survival curves to split up. This shows the need for adequate long-term follow up, and even longer follow-up is probably necessary for sufferers with earlier-stage disease. Third, we chose 1.20 as the higher limit of the hazard ratio for noninferiority because, based on a median survival estimate with continuous therapy of 35 a few months, this hazard ratio would yield a 7-month difference in median survival. At the right time the study was designed, a difference in survival of six months or less as a worst-case situation was deemed to become acceptable if it was balanced by better quality of life.Any stationary posture where energy expenditure is usually low may be detrimental to health, be it sitting or standing, he explained. The results cast doubt on the benefits of sit-stand work stations, which employers are increasingly providing to promote healthy working environments, Hillsdon added.. Alcohol intake directly impacts someone’s intention to have unsafe sex A new study has discovered that alcohol usage directly impacts someone’s intention to have unsafe sex. Basically, the more you drink, the more powerful becomes your purpose to engage in unsafe sex.