VMT, which in the US is known as symptomatic VMA, can be an age-related progressive, sight-threatening condition. It is caused by the vitreous humour having an solid attachment to the macula abnormally, the central part of the retina . The macula provides central eyesight that is necessary for everyday duties such as for example driving, reading and recognizing faces. When the vitreous humour shrinks, the solid attachment results in a pulling push on the retina, which may result in visual distortion, decreased visible acuity and central blindness. When the disease progresses the traction may eventually result in the forming of a hole in the macula . It’s estimated that 250,000 to 300,000 individuals in Europe alone suffer from this condition.Clinically, although ALK and ROS1 rearrangements define different subgroups of NSCLC, there are several important similarities between your two disease subtypes. Individuals with ALK-rearranged NSCLC and those with ROS1-rearranged NSCLC have got similar clinicopathological features. Furthermore, the ALK-rearranged and ROS1-rearranged disease subtypes were both responsive to crizotinib highly, with similar instances to the initial response and similar response rates .22 For both ALK-rearranged NSCLC and ROS1-rearranged NSCLC, responses were observed of the precise kind of rearrangement independently.20 One apparent difference between ALK rearrangement and ROS1 rearrangement in individuals with NSCLC might lie in the durability of the response to crizotinib.